Nootropic Side Effects – Noopept User Experience

January 10, 2024

This is my own experience with the cognitive-enhancement drug Nootropics - I have specifically used Noopept over 8 8-month periods and, unfortunately, my opinion is slightly negative. This means more cons than pros. I wish I could say the drugs were excellent but I can't. Nootropic side effects are quite unpleasant.

You may want to note that I was in my late 40s when I tried it. Significantly older than anyone, as smart drugs are often used among college students to help cram in for exams as much as they can. So this is my honest, genuine experience and I'm neither trying to persuade you to use Noopept nor dissuade you from using it. How you view my report is up to you.

Nootropic Side Effects

Why Noopept? - The Strongest Nootropic

I had a set of exams I had to take over the course of a few years and, being in my late 40s, memorizing anything was becoming increasingly difficult as you can imagine. When I heard about the "smart drugs", I didn't hesitate for a second before getting some for myself online.

Noopept is considered to be one of the strongest Nootropics available and at least >1,000 times stronger than piracetam. Many people would experiment with the dose and, generally take 10-30mg once a day, or 10-20mg at a time but three times a day, etc. If you take more than 100mg, you may experience "brain fog" (lack of mental clarity).

Did You Know?

  • Market Size: The global nootropic market size was valued at approximately $2.17 billion in 2020.
  • Projected Growth: Expected to grow at a compound annual growth rate (CAGR) of around 12.5% from 2021 to 2028.
  • Popular Nootropics: Caffeine is the most widely used nootropic, with over 80% of adults in North America consuming it daily.
  • User Demographics: Around 60% of nootropic users are between the ages of 18 and 34.
  • Reasons for Use: 40% of users take nootropics for improved focus and concentration.

My Medical Background

So I was 48. Healthy and normal, healthy heart, normal blood pressure. I exercise every day, and no longer drink, smoke, or take illegal drugs. No previous record of mental illness or any kind of clinical depression, clinical mood swings, etc. I'm generally very easygoing, you know.

The Effect - Did Noopept Improve My Memory?

I'll go straight to the point - it never did.

First I took a 10mg tablet every evening before the study for a month. I wanted to start with a low dosage and make sure I was still in a normal mental state after a while. Noopept initially gave me constant headaches but at a tolerable level lasting for a couple of hours. Soon I got used to the chemical and after a few days, I no longer had headaches.

After one month, I didn't feel my memory had particularly improved. I spent 3-4 hours for the exam study every day in total; 1-2 hours before I left for work, then 1-2 hours again in the evening. So I started to take the same 10mg tablet twice a day each time before the study. 

Noopept vs Aging

I know this is only a subjective statement, but after 8 months, I decided Noopept was not contributing anything to improve my memory. Is it the case that the Noopept is actually working but my brain's aging and increasingly forgetful at the same speed that I'm not noticing the difference? ...like the graph on the right, I know it's almost like a joke. But this is what I often wondered.

Did You Know?

  • Prescription vs. OTC: About 74% of nootropic substances are over-the-counter, while 26% are prescription-based.
  • Online Sales: Nearly 65% of nootropic sales occur online.
  • Geographical Demand: North America holds the largest share of the nootropic market, followed by Europe.
  • Student Usage: Approximately 15% of university students in the U.S. have tried prescription nootropics for academic purposes.
  • Safety Concerns: About 30% of nootropic users have experienced side effects.

Mood Enlightenment

Noopept enlightened my mood. The drug made me chattier and feel much more positive. It worked particularly well when I had to have an important meeting with my clients. I would just take 10mg an hour or so before the meeting, and it turned me into a quick-thinking advisor guy full of positive jokes and wits. I thought it was great, and was also weary of the temporary effect and the potential of dependency.

Increasing the Dose

Over the weekend I spent all day for the exam study, quite intensely. I started to try 30mg at a time, which made me feel "mentally exhausted". If I took 30mg at 10 am, by noon I would feel so "drained" and would have to have a couple of hours of nap. I often wondered whether I was tired physically or mentally - but often didn't want to sit upright, I needed to lie down, therefore I'd say the pill affected my body physically, as well as mentally.

Did You Know?

  • Regulatory Status: Only 5% of nootropic substances are approved by the FDA as cognitive enhancers.
  • Awareness Level: Roughly 70% of adults are not familiar with the term "nootropic."
  • Product Variety: There are over 80 different types of nootropic substances available.
  • Cognitive Enhancement: 55% of users report a noticeable improvement in cognitive function.
  • Long-Term Use: About 20% of nootropic users have been taking them for more than two years.
Depression

Side Effect - Depression

My exams were over and I stopped taking Noopept regularly. By then the drug was never a memory enhancement pill, but it was a mood-enlightening substance. I continued to take a 10mg tab when I felt I needed to motivate myself. 2-3 times a week (i.e. 10-30mg a week).

I hadn't taken the pill for a week when I noticed my mood had plummeted, and quickly realized I was actually feeling "depressed". I was fairly happy at work and very happy with my personal life, so there's no reason to be depressed. But it felt like my head was buried in the sand, or pressed against the floor, and was never able to get out or get up.

I've never felt this way in my life - the only time was the day after I took a cocaine/ketamine mixture about 10 years ago (while out clubbing, never intended!) I took the feeling of depression quite seriously and decided not to take the Noopept tablets for at least a week to avoid dependence.

And I was fine again after 4-5 days or so, I got myself back - one morning I knew my spirits were high and normal again.

Noopept - Pro's and Con's

I'll summarise what I've just said above. Just one Pro.

Pro

  • Lifts up the mood.

Con's

  • Doesn't work as a memory enhancement for me.
  • Gave me headaches in the first few days.
  • If larger does is taken, it makes me feel exhausted.
  • When stopped using I experienced a come-down.

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Did You Know?

  • Market Segmentation: Dietary supplements make up about 40% of the nootropic market.
  • Income Level of Users: Majority of nootropic users have an annual income above $50,000.
  • Gender Distribution: Men are slightly more likely to use nootropics than women, with a ratio of 55:45.
  • Product Development: Around 25 new nootropic products enter the market each year.
  • Clinical Research: Less than 10% of nootropics have robust clinical research backing their efficacy.
Alternatives To Nootropics

Alternatives To Nootropics

Omega-3 Supplements

I've been using Omega-3 supplements for a while now, and they're pretty cool. They're like a simple, no-fuss way to help your brain. I usually take fish oil capsules, but there are vegan options from algae if that's your thing.

  • Easy to find in any pharmacy or health store.
  • Can support brain health and improve mood.
  • No noticeable side effects for me.

I just pop one with my breakfast, and that's it. They don't work overnight, but over time, I felt a bit sharper and more focused. Plus, they're good for your heart too, so that's a bonus.

Herbal Teas

I've got a whole collection of herbal teas at home. Some favorites are ginkgo biloba, ginseng, and green tea. They're great for a little mental boost without the jitters of coffee.

  • Ginkgo biloba can help with memory.
  • Ginseng is known for boosting energy.
  • Green tea has a gentle caffeine kick plus antioxidants.

I usually have a cup in the afternoon when my energy starts to dip. It's a nice, calming ritual, and I definitely feel more alert afterwards. Plus, they're super easy to make.

B Vitamins

B Vitamins are another go-to for me. I'm talking about B6, B12, and folic acid. They're supposed to be great for brain function and energy levels.

  • Found in multivitamins or as individual supplements.
  • Can help with energy and brain fog.
  • I've noticed better energy on days I take them.

I either take a multivitamin in the morning or just B12 on its own. It's a subtle effect, but I do feel like it helps with my overall energy and mood.

Magnesium

Magnesium is kind of underrated but it's been great for me. It's supposed to be good for relaxation and sleep, which in turn helps with cognitive function.

  • Helps with sleep and relaxation.
  • I take it in the evening.
  • There are different types like magnesium citrate or glycinate.

Ever since I started taking magnesium before bed, I've been sleeping better. And we all know good sleep is super important for a clear head the next day. It's a simple thing, but it makes a big difference.

Adaptogens

Lastly, adaptogens. These are herbal supplements like Ashwagandha, Rhodiola Rosea, and Lion's Mane mushroom. They're supposed to help your body handle stress better.

  • Ashwagandha is great for stress.
  • Rhodiola Rosea can boost energy.
  • Lion’s Mane is said to support brain health.

I've tried Ashwagandha, and it's pretty chill. It's not like you feel it working right away, but over time, I've noticed I'm a bit more relaxed and less frazzled. It's worth a shot if you're dealing with stress.

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About the author 

Ray Flexión

Driven by dreams, grounded by reality, taking revenge on life's challenges. Whatever you say, I stand strong. I'm kind-hearted, though unapologetically true to myself. I stumble but I rise. I am who I am , no excuse.

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  1. Wow, I don’t have any experience with smart pills however I have heard of them and often wondered if they work. It seems clear to me based on your experience that the drug is only a temporary fix.

    The fact that it “wore off” makes me wonder if it isn’t just an upper that allowed you to focus and concentrate for awhile but then just sent you into a downer state. The depression definitely sounds scary. That would probably keep me from every using such a drug. Thanks for the info.

    1. Hi Elizabeth, thanks for your comment! I have done a little research and am still not clear how long the effect of these smart drugs should work for. Students often take the pills whenever they need to enhance and retain the memory, but when they stop taking the pills, will the level of brain function go back to the original state, i.e. before the first pill was ever taken? So I’m not very clear “how temporary” that is.Yes the depression is scary, something no one wants to have. Again this is only my own experience, and I’m not saying you shouldn’t take smart drugs. I’m sure it will work on many.

  2. I get concerned about taking any drugs or supplements. Medications prescribed by the doctor may be necessary but I always ask questions. I like supplements for various issues, but I always ask my doctor first. I never heard of Noopept before but when there are more cons than pros, then it should be a concern. It doesn’t sound like Noopept would be something to take. You experienced so many different things and since there was only one positive and it wasn’t enhancing your memory, I wouldn’t take it either. It looks as though Powerfocus Nootropics is a better product. It may be worth a try.

    1. Hi Rob, thanks for sharing your thoughts. Yes it seems like the wisest idea to consult your doctor before trying out such medicines, I have actually spoken to my doctor but she had little knowledge in cognitive enhancement drugs. Therefore (not surprisingly) her eventual answer was “not recommended”. I think as you get to a certain age, these things can give averse effect more than benefits to your brain, and Noopept seems to give me more bad than good… I’m not taking them now, as I do get depressed the next day – only slightly, but recognisable level. And I think that’s bad enough.Thanks again Rob for your comment.

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